Non Invasive Jacketed Telemetry in Socially-Housed Rats for a Combined Assessment of Respiratory System, Electrocardiogram and Activity Using the DECRO System

1-month toxicology study done in collaboration with Charles River Laboratory team now published!

Etisense is very pleased to announce that the article entitled “Non-Invasive Jacketed Telemetry in Socially-Housed Rats for a Combined Assessment of Respiratory System, electrocardiogram and Activity Using the DECRO System”, reflecting a study conducted with the Charles River teams on the use of the solution in a repeat-dose study, is now officially published in the Journal of Pharmacological and Toxicological Methods. The full paper is available free of charge until 1 September here. 

Study: conducted at Charles River Lyon France Safety Assessment Facilities to determine the tolerability and the integrity of DECRO used in pair-housed rats. Repeated sessions of 22 hours each simulating the inclusion of safety pharmacology endpoints in a 1-month toxicology study with administration of a reference compound inducing cardiorespiratory changes (Baclofen – GABAB receptor agonist).
 
Main results: Jacket was well tolerated, resistant to deterioration. It allowed the accurate recording, in a non-invasive manner, of cardiorespiratory parameters and activity level in freely moving pair-housed rats. Expected respiratory and activity depressant effects of baclofen recorded.
 
Perspectives: DECRO system could be an alternative to safety pharmacology core battery WBP studies to evaluate acute respiratory effects of a candidate compound. Beyond strict regulatory use, the combination of the ECG, respiration and spontaneous activity measurements in freely moving rats can be relevant for early safety assessment and tolerability studies.

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