Implementation of Cardiorespiratory Monitoring in the Juvenile Minipig Using a Noninvasive Jacketed Telemetry System

PENARD L², FLENET T¹, EYNARD C¹, BOUILLON C¹, BORY C², BAUDET S², MARSDEN E².

¹ ETISENSE SAS, Lyon, France
² Charles River Laboratories France Safety Assessment SAS, Lyon, France.

Society for Birth Defects Research & Prevention 61st Annual Meeting June 24–July 1, 2021

https://doi.org/10.1002/bdr2.1928

  • The Göttingen Minipig is widely accepted as a non-rodent species for safety testing, including juvenile studies, thanks to physiological similarities with man, large litter size and rapid postnatal development through to sexual maturity.
  • Piglets can be used for laboratory procedures from a very early age, even from postnatal day (PND) 1 onwards due to a high degree of autonomy shortly after birth.
  • Cardiorespiratory assessments may need to be included in non-rodent juvenile animal studies performed to support the development of pediatric pharmaceutical candidates.
  • Cardiovascular assessments in adult minipigs are well established but this is not the case for juveniles, especially in younger animals prior to weaning.
  • A non-invasive method was developed to collect cardiorespiratory and activity data in the juvenile minipig that address both ethical and scientific concerns. This method was implemented with DECRO® jacket, already commercialized for the rat by Etisense, and uses Bluetooth Low Energy® technology for signal transmission.