Pharmacology and Safety-Toxicology
Safety and efficacy assessment for new pharmacological compounds.
Why it matters?
Preclinical safety pharmacology requires robust cardiorespiratory and activity assessment across both rodent and non-rodent models.
DECRO® provides a unified telemetry platform engineered to evaluate cardiac, respiratory, and motor functions seamlessly across multiple species – including rats, marmosets, dogs, and pigs.
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One Platform, Multiple Species: Standardize hardware and software across your facility to maximize ROI, streamline workflows, and shorten learning curves.
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Comprehensive Physiology: Capture continuous ECG, respiration, and actigraphy data in conscious, freely moving animals.
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Full GLP Compliance: Built for regulated environments and already trusted by leading CROs in GLP-compliant studies.
Looking for a CRO partner offering NON-GLP or GLP safety assessment services with DECRO?
This approach allows for :
Rapid and Cost-effective pharmacological studies for decision making (only a few minutes per animal and no specialized technical expertise). In addition, jackets are significantly more cost-effective, priced three to five times lower than typical refurbished telemetry implants.
Reducing Severity (Refining) through its completely non-invasive nature, eliminating potential harm, surgery, and related pain for the animals. As a result, it aligns with animal welfare regulations and ethical committee requirements (e.g., EU Directive 2010/63, NIH guidelines), while supporting social housing and interactions.
Unrestrained, Extended-Duration Safety Assessment, aligning with best practices for cardiovascular telemetry (e.g. ICH E14/S7B Q&A 5.1, 6.1) and enabling longitudinal assessment to offer a full picture of potential delayed and chronic effects.
Streamlined preclinical evaluation aligned with ICH M3(R2) and ICH S6 guidelines. This provide a unique opportunity to reduce animal use and eliminate the need for separate studies by integrating safety endpoints directly into repeat-dose and general non-GLP and GLP toxicology studies.
Use Cases
Discover how DECRO can support your safety and efficacy studies.
Early Drug De-risking
DECRO’s minimal-overhead integration early in drug development is invaluable for early de-risking, allowing for the timely identification of potential adverse effects and better informing subsequent studies.
Example: a pharmaceutical or biotech company can seamlessly incorporate DECRO into a rat preclinical Dose Range Finding (DRF) study with minimal impact on established protocols. The rich cardiorespiratory endpoints provided offer functional insights, enabling a comprehensive assessment of the dose-response relationship. This, in turn, facilitates a more precise analysis of both the efficacy and safety profile of the investigational drug, streamlining the development process and reducing the risk of late-stage failures.
Efficacy - Disease Models
DECRO offers a sophisticated approach for evaluating the pharmacological effects of novel compounds on disease models. Its non-invasive nature provides a distinct advantage by preventing additional stress on models already compromised by their condition, thus ensuring more accurate and representative data.
Example: non-invasive ECG assessment can be readily employed in rat Chronic Kidney Disease (CKD) models to evaluate the efficacy of mineralocorticoid receptor antagonists. This lightweight approach allows for continuous, high-fidelity monitoring of cardiac function without imposing further burden on the animals, providing precise insights into treatment response.
Regulatory Safety Pharmacology and Toxicology
Assessing acute and potentially life-threatening risks of novel pharmaceuticals is a critical step in IND-enabling studies with a primary focus set on the cardiovascular, respiratory, and central nervous systems, in line with ICH S7 and S6 guidelines for safety assessment. In this contexte, DECRO offers robust capabilities for safety assessment in both rodent and non-rodent species (dogs, minipigs, and marmosets) with comprehensive respiratory core battery assessment and Electrophysiological evaluation in unrestrained animals, including extended-duration QT prolongation assessment (ICH E14/S7B). Moreover, non-invasive jacketed telemetry systems ease the implementation of standalone safety pharmacology studies or, more beneficially, smoothly integrate into combined designs as recommended by ICH M3(R2). As a result, this allows CROs to propose enhanced ICH S7 core battery safety pharmacology studies to their sponsors.
Examples of use
In rodents, DECRO facilitates the integration of ICH S7 Core Battery CNS and respiratory endpoints into a single study design, thereby significantly improving development time and resource utilization (link to ERBC paper).
Similarly, in non-rodent studies, jacketed telemetry enables efficient repeated evaluation of safety endpoints within repeated-dosing toxicology studies (e.g., 4 or 13 weeks). This integrated approach efficiently provides robust safety data without increasing the overall animal burden required for the IND submission package.
Resources on Pharmacology and Safety-Toxicology
A New Telemetry Jacket for Dogs
Agathe Cambier, Msc, Product and Application Specialist; Clémence Nadjar, Textile Engineer Why a telemetry jacket for dogs? Telemetry jackets have been used since the late 2000s in regulatory safety studies on medium-sized animals such as dogs, primates, and minipigs...
Etisense will attend the Safety Pharmacology Society 2025 annual meeting
Etisense will be exhibiting at the Annual Safety Pharmacology Society Meeting, October 13–15 at Jaarbeurs Utrecht! This event is the perfect opportunity to showcase our latest innovations in jacketed telemetry targeting dogs and minipigs, built upon the solid...
Etisense and Marshall BioResources Europe join forces to rethink research practices
Etisense and Marshall BioResources Europe Collaborate to Develop an Innovative Telemetric Jacket for Beagle DogsLyon, France – 06 May, 2025 – Etisense, a French biomedical engineering company specializing in wearable telemetry for preclinical research, is proud to...
Jacketed telemetry in rats: a novel non-invasive method for cardiorespiratory phenotyping during treadmill exercise
Stephane Tanguy1, Agathe Cambier2, Leandro Fontana-Pires1,2, Timothe Flenet2, Charles Eynard2, Julie Fontecave-Jalon1, Pierre-Yves Gumery1 and François Boucher1 1 Universite Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, T IMC, 38000 Grenoble, France2...
Explore Other Applications
Phenotyping of disease models
Monitoring of ECG morphological changes, ventilation, and locomotor activity patterns changes to better characterize pathological phenotypes and understand underlying pathophysiological mechanisms.
Monitoring of vital functions
Monitor the health status of your animals following a medical condition or surgery (e.g., cardiac stroke), or anticipate humane endpoints in severe procedures using jacketed telemetry — all while allowing a return to the home cage.
Education and Training
Learn physiology and pharmacology using jacketed telemetry on rehomed animals, or through a new digital approach with pre-recorded, on-demand datasets from cardiorespiratory studies.
Veterinary
Use wearable telemetry to monitor vital signs (heart and respiratory rates) or the development of medical conditions (e.g., cardiopathy), either at home or at the veterinary clinic.